Mevastatin - Wikipedia
网页Mevastatin (compactin, ML-236B) is a hypolipidemic agent that belongs to the statins class. It was isolated from the mold Penicillium citrinum by Akira Endo in the 1970s, and he identified it as a HMG-CoA reductase inhibitor, [1] i.e., a statin.
Mevastatin: Uses, Interactions, Mechanism of Action - DrugBank …
网页2010年3月13日 · Mevastatin or compactin is a cholesterol-lowering agent isolated from Penicillium citinium. It was the first discovered agent belonging to the class of cholesterol-lowering medications known as statins.
Mevastatin | C23H34O5 | CID 64715 - PubChem
网页Mevastatin or compactin is a cholesterol-lowering agent isolated from Penicillium citinium. It was the first discovered agent belonging to the class of cholesterol-lowering medications known as statins.
Statins: Are these cholesterol-lowering drugs right for you?
网页2024年3月6日 · Statins also may help reduce the risk of certain blood clots. A number of statins are available for use in the United States. They include: Atorvastatin (Lipitor). Fluvastin (Lescol XL). Lovastatin (Altoprev). Pitavastatin …
Mevastatin - an overview | ScienceDirect Topics
网页Mevastatin is a natural product initially identified in the 1970s, known for its potent inhibition of HMG-CoA reductase and ability to lower serum cholesterol levels in animals. AI generated definition based on: Comprehensive Medicinal Chemistry II , 2007
Mevastatin - an overview | ScienceDirect Topics
网页Compactin (also known as mevastatin) is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme-A reductase, an enzyme required for the biosynthesis of UBIAD1 side chain substrate geranylgeranyl diphosphate (Hirota et al., 2015) and of cholesterol.
Your Guide to Statins: Everything You Need to Know - Healthline
网页2024年5月2日 · Statins offer several benefits for heart health, including: Reducing LDL cholesterol: Statins are highly effective at reducing levels of LDL cholesterol, often referred to as “bad” cholesterol...
Statins: How They Work & Side Effects - Cleveland Clinic
网页2024年3月12日 · Statins. Statins are prescription drugs people take to lower their level of LDL or “bad” cholesterol that builds up in arteries. Statins work by interfering when your liver makes cholesterol. Most people can take statins without bad side effects. Your healthcare provider will look at your specific situation and decide if a statin is right ...
Statins: a viable candidate for host-directed therapy against
网页2018年11月28日 · By promoting host defence mechanisms and inhibiting pathological inflammation, statins increase survival in human infectious diseases. At the cellular level, statins inhibit the intermediates...
Mevastatin - an overview | ScienceDirect Topics
网页Mevastatin (compactin) (Fig. 2) is a hexahydronaphthalene containing a chiral β-hydroxy-δ-lactone. Compactin was first isolated from microbial fermentations of Penicillium citrinum in 1971 by Endo and co-workers at Sankyl. 5 It was found to be a potent competitive inhibitor of HMG-CoA reductase.