Triphosgene - Wikipedia
网页Triphosgene (bis (trichloromethyl) carbonate (BTC) is a chemical compound with the formula OC (OCCl 3) 2. It is used as a solid substitute for phosgene, which is a gas and diphosgene, which is a liquid. [5][6] Triphosgene is stable up to 200 °C. [7]
A decade review of triphosgene and its applications in organic ...
网页2020年11月20日 · This review article highlights selected advances in triphosgene-enabled organic synthetic reactions that were reported in the decade of 2010–2019. Triphosgene is a versatile reagent in organic synthesis. It serves as a …
A decade review of triphosgene and its applications in organic ...
网页2020年11月11日 · Triphosgene, also known as bis(trichloromethyl) carbonate or BTC, is a convenient substitute for the extremely toxic phosgene gas (Fig. 1). It exists as a stable crystalline solid with a melting point of 80 °C, but it decomposes at …
A decade review of triphosgene and its applications in organic ...
网页2020年11月20日 · Triphosgene is a versatile reagent in organic synthesis. It serves as a convenient substitute for the toxic phosgene gas. Despite its first known preparation in the late 19th interestingly began only three decades ago.
Bis(trichloromethyl)carbonate (BTC, Triphosgene): A Safer …
网页2017年8月11日 · Bis (trichloromethyl)carbonate (BTC, triphosgene) is a versatile compound that enables highly efficient syntheses. In addition, because of its solid state, it is a very convenient compound for small-scale phosgenations. Consequently, this compound is favored as a phosgene substitute in research and development and in small-scale …
Bis(trichloromethyl) carbonate | C3Cl6O3 | CID 94429 - PubChem
网页Triphosgene | C3Cl6O3 | CID 94429 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Triphosgene | C3Cl6O3 - ChemSpider
网页ChemSpider record containing structure, synonyms, properties, vendors and database links for Triphosgene, 32315-10-9, 250-986-3
Triphosgene, a Crystalline Phosgene Substitute - ResearchGate
网页1987年9月1日 · Abstract. Thermally stable, not very volatile, easy to transport and to store, accurately dosable—these are the advantages of solid triphosgene (bistrichloromethylcarbonate, BTC) as a substitute...
Triphosgene and its Application in Organic Synthesis
网页2016年10月28日 · In this study, we want to have an extensive overview on the application of triphosgene in organic synthesis. We begin with an introductory discussion of the nature of triphosgene, and introduce...
Triphosgene - chemeurope.com
网页Triphosgene (Bis (trichloromethyl) carbonate, C 3 Cl 6 O 3) is a chemical compound that is used as a substitute for phosgene. At room temperature, the compound is a white crystalline solid that decomposes around 130 °C. The decomposition temperature of impure …
Triphosgene reagent grade, 98 32315-10-9 - MilliporeSigma
网页Triphosgene [Bis(trichloromethyl)carbonate] is a versatile organic reagent used in organic synthesis alternative to phosgene. A catalytic amount of triphosgene is particularly used in chloroformylations, carbonylations, chlorinations, and dehydration reactions.
In situ photo-on-demand phosgenation reactions with chloroform …
网页2023年6月6日 · To reduce the safety risk, in situ production of phosgene via decomposition of triphosgene (BTC), which is a solid at room temperature and soluble in organic solvents, with organic bases [Fig....
A decade review of triphosgene and its applications in organic ...
网页2020年11月1日 · Triphosgene: an efficient chlorination reagent for synthesis of 5-chloro-2-pentanone from 3-acetyl-1-propanol. 5-Chloro-2-pentanone (5C2P) and its derivatives are widely utilized in the pharmaceutical and agrochemical industry. A new catalytic approach was proposed to convert 3-acetyl-1-propanol to 5C2P using….
Bis(trichloromethyl)carbonate (BTC, Triphosgene): A Safer …
网页Bis(trichloromethyl)carbonate (BTC, triphosgene) is a versatile compound that enables highly efficient syntheses. In addition, because of its solid state, it is a very convenient compound for small-scale phosgenations.
Triphosgene - Common Organic Chemistry
网页Triphosgene decomposes to highly toxic phosgene on heating or with exposure to nucleophiles including H2O.
Phosgene Toxicity Clinical Manifestations and Treatment: A …
网页2024年2月28日 · This study reviewed systematically 13 studies on the mechanism, clinical symptoms, and treatment of phosgene exposure. Previous studies (12, 13, 30 - 34) outline the intricate mechanisms of P-ALI, emphasizing the role of pulmonary oedema, inflammation, and oxidative stress.
A decade review of triphosgene and its applications in organic ...
网页2020年11月20日 · This review article highlights selected advances in triphosgene-enabled organic synthetic reactions that were reported in the decade of 2010–2019. Triphosgene is a versatile reagent in organic synthesis. It serves as a …
Phosgene inhalation toxicity: Update on mechanisms and …
网页2021年2月28日 · Especially in research laboratories with limited inhalation equipment, experience, and expertise, triphosgene has frequently been used instead of phosgene, but the results have been published under the umbrella of …
Triphosgene: an efficient chlorination reagent for synthesis of 5 ...
网页2022年11月28日 · 5-Chloro-2-pentanone (5C2P) and its derivatives are widely utilized in the pharmaceutical and agrochemical industry. A new catalytic approach was proposed to convert 3-acetyl-1-propanol to 5C2P using bis(trichloromethyl)carbonate (triphosgene, BTC) as the efficient chlorine source.
Phosgene - Wikipedia
网页Phosgene is used to produce chloroformates such as benzyl chloroformate: R−OH + COCl2 → R−O−C (=O)−Cl + HCl. In these syntheses, phosgene is used in excess to prevent formation of the corresponding carbonate ester. With amino acids, phosgene (or its trimer) reacts to give amino acid N-carboxyanhydrides.
(PDF) A decade review of triphosgene and its applications in …
网页Triphosgene is a versatile reagent in organic synthesis. It serves as a convenient substitute for the toxic phosgene gas. Despite its first known preparation in the late 19th interestingly began only three decades ago.
Phosgenation Reactions with Phosgene from Triphosgene
网页2011年12月20日 · Triphosgene was decomposed quantitatively to phosgene by chloride ion. The reaction course was monitored by IR spectroscopy (React-IR), showing that diphosgene was an intermediate.
Phosgene and Phosgene Substitutes - MilliporeSigma
网页Phosgene and Phosgene Substitutes. Because phosgene is a poisonous gas, many attempts have been made to substitute it with phosgene equivalents. The most common substitutes are diphosgene (DP; 15,159-9), triphosgene (TP; 33,075-2), carbonyl diimidazole (CDI; 11,553-3), disuccinimidyl carbonate (DSC; 22,582-7).