Although you may never have heard of the cytochrome P450 superfamily of enzymes, these proteins play diverse and critical roles in humans through the metabolic processing of drugs, pesticides ...

In the September 20 Nature Communications, scientists led by Andrew Saykin at Indiana University School of Medicine, Indianapolis, reported that a risk variant of CYP1B1, a member of the cytochrome ...

Of particular importance are cytochrome P450 enzymes, heme-containing mono-oxygenases which catalyze the final step in the incorporation of oxygen into organic molecules. They convert xenobiotics ...

H ealth outcomes in humans often show daily variations. For instance, morning vaccinations may trigger a more effective ...

Funding will support metabolism studies of ALX-001, a first-in-class oral therapy in clinical development for Alzheimer’s ...

Your body has enzymes, such as the cytochrome p450 (CYP) and others, that process many types of medications. This is called metabolism. It also has a way to get rid of drugs, usually though your ...

Despite knowing that the active centres of many metalloprotein enzymes are iron porphyrin ... can mimic the activity of various types of cytochrome P450. Can the catalytic activity and reaction ...

Tamoxifen is metabolized to more active metabolites by enzymes encoded by polymorphic genes, including cytochrome P450 2D6 (CYP2D6). Tamoxifen is a substrate for ATP-binding cassette transporter ...

Francis Yoshimoto, an assistant professor in the UTSA College of Sciences’ Department of Chemistry, is leading a team that developed an anti-obesity drug that blocks the effects of cytochrome P450 8B1 ...

When metabolism of cinacalcet by the cytochrome P450-related liver enzyme CYP3A4 is inhibited by ketoconazole, itraconazole, voriconazole, telithromycin or ritonavir, cinacalcet dose should be ...

The ritonavir in Paxlovid blocks some critical pathways that metabolize (break down) drugs. Specifically, Paxlovid blocks both the liver enzyme cytochrome P450 3A4 and p-glycoprotein. This results in ...

Drug Metabolism and Disposition, 42: 1132-6. Gates LA, Lu D, & Peterson LA (2012). Trapping of cis-2-butene-1,4-dial to measure furan metabolism in human liver microsomes by cytochrome P450 enzymes.