Of particular importance are cytochrome P450 enzymes, heme-containing mono-oxygenases which catalyze the final step in the incorporation of oxygen into organic molecules. They convert xenobiotics ...

A lthough you may never have heard of the cytochrome P450 superfamily of enzymes, these proteins play diverse and critical roles in humans through the metabolic processing of drugs, pesticides ...

Despite knowing that the active centres of many metalloprotein enzymes are iron porphyrin ... can mimic the activity of various types of cytochrome P450. Can the catalytic activity and reaction ...

In the September 20 Nature Communications, scientists led by Andrew Saykin at Indiana University School of Medicine, Indianapolis, reported that a risk variant of CYP1B1, a member of the cytochrome ...

H ealth outcomes in humans often show daily variations. For instance, morning vaccinations may trigger a more effective ...

Tamoxifen is metabolized to more active metabolites by enzymes encoded by polymorphic genes, including cytochrome P450 2D6 (CYP2D6). Tamoxifen is a substrate for ATP-binding cassette transporter ...

Funding will support metabolism studies of ALX-001, a first-in-class oral therapy in clinical development for Alzheimer’s ...

How does your body speed up these important reactions? The answer is enzymes. Enzymes in our bodies are catalysts that speed up reactions by helping to lower the activation energy needed to start a ...

Comparative metabolism of furan in rodent and human cryopreserved hepatocytes. Drug Metabolism and Disposition, 42: 1132-6. Gates LA, Lu D, & Peterson LA (2012). Trapping of cis-2-butene-1,4-dial to ...

Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with CANNABIS Some medications are changed and broken down by the liver. Cannabis might change how quickly the ...

When metabolism of cinacalcet by the cytochrome P450-related liver enzyme CYP3A4 is inhibited by ketoconazole, itraconazole, voriconazole, telithromycin or ritonavir, cinacalcet dose should be ...

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with IPRIFLAVONE Some medications are changed and broken down by the liver. Ipriflavone might decrease how ...