During DNA replication, the unwinding of strands leaves a single strand vulnerable. How does the cell protect these strands from damage? How would you identify the protein that serves as a ...

来自日本RIKEN生物系统动力学研究所的Ichiro Hiratani研究团队和Tomoya S. Kitajima研究团队合作在Nature杂志上发表题为Embryonic genome instability upon DNA replication ...

As for cellular DNA replication, significant advances in ... including the size and complexity of eukaryotic genomes, genetic and protein nomenclature for different organisms, alternative names ...

coli bacteriophages T4, T6, T7, and T3, encode their own ATP-dependent DNA ligases. ATP-dependent DNA ligases are also encoded by eukaryotic DNA viruses that conduct some or all of their replication ...

To understand the molecular mechanisms by which eukaryotic cells carry out and monitor accurate genome replication we employ a fully reconstituted DNA replication system based on purified proteins ...

During DNA replication, special enzymes move up along the DNA ladder, unzipping the molecule as it moves along. New nucleotides move in to each side of the unzipped ladder. The bases on these ...

Original DNA template - DNA is a double helix made of two complementary strands. Each strand can be used as a template to create a new DNA molecule. Free DNA nucleotides – needed to form the new ...

The basic enzymology of DNA replication is well conserved among all life, and it has recently been shown that eukaryotic chromosomes are also highly catenated along their lengths. We expect that our ...

Cells have effective DNA repair mechanisms at their disposal. A research team at the University of Würzburg has now gained new insights into the DNA damage response.

The enormously long genomic DNA molecules in eukaryotic organisms must be tightly ... as well as for DNA replication, repair, ...

Genetic material DNA in a nucleus, plasmids are found in a few simple eukaryotic organisms. DNA is a single molecule, found free in the cytoplasm; additional DNA is found on one or more rings ...

The unit covers fundamental aspects of molecular biochemistry, including enzyme activity, DNA replication and translation, and the synthesis of proteins. Lectures on the content of the unit are ...