A bioinformatics pipeline describes 390 putative, novel inhibitory receptors, to facilitate targeted therapeutic strategies for diverse immune cell types in cancer therapy.

In resting macrophages that sample their environment through low-avidity basal ligation of ITAM-coupled receptors, PKC, MAPK and NF-κB activity is low, but intracellular calcium levels are ...

Find out about Resolution Therapeutics' macrophage therapy, as it just raised $85 million in a series B round.

Macrophages have important roles in the induction ... a recent study demonstrates that the P2X4 receptor mediates inflammatory pain by inducing formation of the potent lipid mediator prostaglandin ...

These function as "eat me" signals to the macrophages, which detect them via Fc receptors (FcR) embedded in their cell ...

A high density of tumor-associated macrophages (TAMs) is associated with poorer prognosis and survival in breast cancer patients. Recent studies have shown that lipid accumulation in TAMs can promote ...

This also suggests that macrophages, part of the innate immune system, have a mechanism for immunological memory, a trait that scientists until recently had only observed in the adaptive adaptive ...

Initially mistaken for neutrophils, a population of atypical macrophages appears in the lungs after severe viral infection, ...

Subcutaneously administered AK006 showed approximately 77% bioavailability and prolonged receptor occupancy on mast cells –– Subcutaneous AK006 ...

In the fight against cancer, chimeric antigen receptor T cell (CAR-T) therapy has achieved notable success in treating ...

T cell therapy has achieved notable success in treating blood cancers. However, it has been largely ineffective against solid tumors. A study demonstrates that a different immunotherapy approach ...