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腾讯网
21d
覃江江/程向东团队开发GPX4降解药物,触发癌细胞铁死亡
覃江江课题组前期开发了靶向GPX4的小分子抑制剂(Eur J Med Chem 2024),但因GPX4的结合口袋较浅,如经典的GPX4小分子抑制剂RSL3、ML162等,均在药代动力 ...
生物谷
6d
Mol Cell:OPA1协调线粒体ROS和整合应激反应调控细胞铁死亡
有趣的是,OPA1在通过半胱氨酸剥夺和xGT抑制剂(erastin)导致的线粒体ROS和脂质ROS积累中发挥作用,而在通过GPx4抑制剂(RSL3)引发的ROS积累中不发挥 ...
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