Tamoxifen is metabolized to more active metabolites by enzymes encoded by polymorphic genes, including cytochrome P450 2D6 (CYP2D6). Tamoxifen is a substrate for ATP-binding cassette transporter ...

When metabolism of cinacalcet by the cytochrome P450-related liver enzyme CYP3A4 is inhibited by ketoconazole, itraconazole, voriconazole, telithromycin or ritonavir, cinacalcet dose should be ...

"Poor metabolizer," "prodrug," "CYP2D6." Let's explore what these terms mean and what this all means for Dan. Cytochrome P450, often referred to as CYP or "sip," is a family of enzymes responsible for ...

A team of researchers from the Hebrew University of Jerusalem, the Weizmann Institute of Science, and the University of Tokyo has made a significant breakthrough in the fight against cancer by ...

Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. They include very small molecules, such as urea, and complex structures, such ...

Enzyme mechanisms are the chemical transformations, and the steps within them, generated by enzymatic action on substrates. The mechanism of enzyme catalysis is similar in principle to other types ...