[22] Massive accidental overdosages of esmolol due to dilution errors, resulting in both fatalities and permanent disability, have been reported. [77] Bolus doses in the range of 625 mg to 2.5 g ...
Esmolol is an intravenous, ultra-short-acting b-adrenergic blocker. Onset of effect is seen within 1-5 minutes, with a rapid offset of effect within 15-30 minutes following discontinuation.