Substrates of Aurora A of significant interest include the tumour suppressor p53, and BRCA1 ... might have a specific role in male meiosis. PLK1 is highly expressed in cells with a high mitotic ...

During the cell cycle, the activation of Plk1 relies on the phosphorylation at T210 within the activation segment, which is performed by another kinase Aurora A. This process requires a cofactor ...

The findings were recently published in Communications Chemistry. p53 is central to the body's defense against cancer, tasked with regulating the cell cycle and triggering the death of damaged ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

We have thus uncovered a Plk1- and CEP295-dependent mechanism whereby duplication ... revealing a new level of control in cilia sensation. A novel p53-dependent stress response pathway that functions ...

在这项新的研究中，研究者利用生物物理、生物化学、结构生物学和细胞生物学技术更好地了解了 PLK1 的作用。 着丝粒（centromere）是DNA的一个区域 ...

Retraction Note: M2 macrophage-derived extracellular vesicles promote gastric cancer progression via a microRNA-130b-3p/MLL3/GRHL2 signaling cascade. Retraction Note ...