研究人员制备的水凝胶对肿瘤微环境的活性氧物种（ROS）敏感。特别是，在水凝胶中负载的铁死亡诱导剂RSL3可以触发肿瘤铁死亡。令人惊讶的是，在ROS响应水凝胶中包裹的RSL3通过增加肿瘤浸润的CD4+ T细胞、CD8+ T细胞和M1巨噬细胞的数量，同时减少M2巨噬细胞的 ...

Lab tests highlighted the prosthesis's potential; it released RSL3 upon detecting 'reactive oxygen species', inducing cell death in tumor remnants left in mice. Considerable anti-cancer effects were ...

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We observed an increase in Wnt5a secretion in H9C2 cardiac cells upon treatment with ferroptosis inducers such as ferric ammonium citrate (FAC 2 mM) and RSL3 (20 nM). Live/Dead viability analyses in ...

有趣的是，OPA1在通过半胱氨酸剥夺和xGT抑制剂（erastin）导致的线粒体ROS和脂质ROS积累中发挥作用，而在通过GPx4抑制剂（RSL3）引发的ROS积累中不发挥 ...

Resveratrol, a naturally occurring polyphenolic compound, has captivated the scientific community with its promising therapeutic potential across a spectrum of diseases. This review explores the ...

覃江江课题组前期开发了靶向GPX4的小分子抑制剂（Eur J Med Chem 2024），但因GPX4的结合口袋较浅，如经典的GPX4小分子抑制剂RSL3、ML162等，均在药代动力 ...

铁死亡是一种铁依赖的非凋亡性细胞死亡形式，这种细胞死亡形式与传统的细胞凋亡、坏死等形式不同，主要由细胞内铁的积累以及脂质过氧化引发【1, 2】。细胞内存在抗氧化机制试图抑制这些氧化物的积累，其中谷胱甘肽过氧化物酶4（GPx4）是抵御铁死亡的 ...