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中国科学技术大学魏海明团队:揭示p53调节肿瘤免疫微环境的潜在机制
【导读】作为癌症中最常见的基因改变,超过一半的人类癌症具有导致转录失活的p53突变。然而,p53如何调节免疫景观以创造免疫逃逸的生态位,仍然难以捉摸。团队发现癌症干细胞(CSCs)建立了白细胞介素34(IL-34)编排的生态位,以促进p53灭活肝癌的肿瘤发生 ...
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