Cholesterol metabolism: physiological regulation and diseases
网页2024年2月24日 · In this review, we will describe the primary pathways and regulations of various key aspects of cholesterol metabolism, establishing a crucial foundation for understanding the relationship between cholesterol metabolism and diseases in the subsequent text.
Cholesterol: Synthesis, Metabolism, and Regulation
网页2024年9月9日 · Pathway of cholesterol biosynthesis. Synthesis of cholesterol begins with the transport of acetyl-CoA from within the mitochondria to the cytosol. The rate limiting step in cholesterol synthesis occurs at the 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, HMGR, catalyzed step.
Mechanisms and regulation of cholesterol homeostasis
网页2019年12月17日 · The cellular cholesterol level reflects the dynamic balance between biosynthesis, uptake, export and esterification — a process in which cholesterol is converted to neutral cholesteryl esters...
Cholesterol Metabolism | Physiology - Geeky Medics
网页2010年11月11日 · A brief overview of cholesterol metabolism including types of lipoproteins, exogenous pathway, endogenous pathway and the reverse cholesterol transport pathway.
Lipid Metabolism - PMC - National Center for Biotechnology …
网页The cholesterol biosynthetic pathway initiates in the cytosol and is controlled by the enzyme 3-hydroxy-3-methylglutaryl CoA reductase (HMG-CoA reductase), the target of statins (class of cholesterol-lowering drugs).
Regulation of cholesterol homeostasis in health and diseases: …
网页2022年8月2日 · Disturbed cholesterol homeostasis plays critical roles in the development of multiple diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and cancers, particularly the...
Cholesterol metabolism pathways – are the intermediates more …
网页2021年2月17日 · The major route of cholesterol metabolism is conversion to bile acids. Bile acids themselves are interesting molecules being ligands to nuclear and G protein‐coupled receptors, but perhaps the intermediates in the bile acid biosynthesis pathways are even more interesting and equally important.
Mechanisms and regulation of cholesterol homeostasis
网页In this Review, we discuss the latest advances regarding how each of the four parts of cholesterol metabolism is executed and regulated. The key factors governing these pathways and the major mechanisms by which they respond to …
Lipid metabolism - Wikipedia
网页Cholesterol can be made from acetyl-CoA through a multiple-step pathway known as isoprenoid pathway. Cholesterols are essential because they can be modified to form different hormones in the body such as progesterone .
Cholesterol metabolism - Reference pathway - KEGG
网页Cholesterol homeostasis in humans is regulated by well-balanced mechanisms of intestinal uptake, endogenous synthesis, transport in lipoprotein particles, and biliary excretion. Its abnormal metabolism can lead to increased risk for various endocrine disorders and cardiovascular diseases.