More from Cancer Cell - Cell Press
Cancer Cell provides a high-profile forum to promote major advances in cancer research and oncology. The primary criterion for considering manuscripts is whether the studies provide major advances into answering important questions relevant to naturally occurring cancers.
Conserved pan-cancer microenvironment subtypes predict ... - Cell …
Here, we developed an accessible transcriptomic analysis platform for TME classification to identify functional gene sets defined by cellular populations, signaling signatures, TME processes, and cancer cell properties that ensure comprehensive characterization of both …
New articles: Cancer Cell
5 天之前 · Cancer cells often evade the host immune system, challenging the effectiveness of immunotherapy. In this comprehensive review, Galassi et al. summarize key mechanisms of immune evasion within the “three Cs” framework—camouflage, coercion, and cytoprotection—and discuss promising strategies to target these mechanisms for therapeutic ...
Issue: Cancer Cell
2024年10月14日 · Three recent publications, including a study by Fitzsimons et al. in this issue of Cancer Cell, use single-cell RNA sequencing to define pan-cancer atlases of tumor-infiltrating B cell subsets, paving the way for profound advances in our understanding of B cell-dependent antitumor immunity.
Immune phenotypic linkage between colorectal cancer and
2022年4月11日 · The tumor-progression process in each organ could be different due to the interplay between cancer cells and the unique resident immune cells. Our results enhance our understanding of the impact of both the cancer-cell properties and the tissue of …
Comprehensive peripheral blood immunoprofiling reveals ... - Cell …
2024年5月13日 · T cell repertoire in peripheral blood as a potential biomarker for predicting response to concurrent cetuximab and nivolumab in head and neck squamous cell carcinoma.
A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell ...
2023年7月13日 · Our findings reveal an intratumoral phase of the anti-cancer T cell response orchestrated by tumor-residing cDC1 that determines protective versus ineffective immunity and could be exploited for cancer therapy.
Proteogenomic data and resources for pan-cancer analysis - Cell …
2023年8月14日 · Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune evasion mechanisms
Redefining breast cancer subtypes to guide treatment ... - Cell Press
Breast cancer treatment now includes platinum-based agents, poly (ADP-ribose) polymerase (PARP) inhibitors, phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) inhibitors, mammalian target of rapamycin (mTOR) inhibitors, dual HER2-targeting regimens, and immunotherapy for specific HR/HER2-defined subtypes (Bergin and Loi, 2019 ...
Classifying cancer-associated fibroblasts—The good, the ... - Cell …
2024年9月9日 · Cancer-associated fibroblasts (CAFs) are heterogeneous and ubiquitous stromal cells within the tumor microenvironment (TME). Numerous CAF types have been described, typically using single-cell technologies such as single-cell RNA sequencing.