The structural basis of fatty acid elongation by the ELOVL …
网页2021年6月10日 · Very long chain fatty acids (VLCFAs) are essential building blocks for the synthesis of ceramides and sphingolipids. The first step in the fatty acid elongation cycle is catalyzed by the...
Fatty acid synthesis - Wikipedia
网页In biochemistry, fatty acid synthesis is the creation of fatty acids from acetyl-CoA and NADPH through the action of enzymes called fatty acid synthases. This process takes place in the cytoplasm of the cell .
A comprehensive review of the family of very-long-chain fatty acid ...
网页2023年11月20日 · The family of very-long-chain fatty acid elongases (ELOVL1-ELOVL7) plays a crucial role in cellular metabolism by facilitating the elongation of fatty acids beyond the typical chain length.
The structural basis of fatty acid elongation by the ELOVL ... - PubMed
网页Very long chain fatty acids (VLCFAs) are essential building blocks for the synthesis of ceramides and sphingolipids. The first step in the fatty acid elongation cycle is catalyzed by the 3-keto acyl-coenzyme A (CoA) synthases (in mammals, ELOVL elongases).
6.12: Fatty Acid Synthesis - Biology LibreTexts
网页2023年8月31日 · Elongation of Fatty Acids. Elongation to make fatty acids longer than 16 carbons occurs in the endoplasmic reticulum and is catalyzed by enzymes described as elongases. Mitochondria also can elongate fatty acids, but their starting materials are generally shorter than 16 carbons long.
Fatty acid elongation by ELOVL condensing enzymes depends on a ... - Nature
网页2021年6月10日 · Fatty acid elongation is initiated by a condensation reaction (1) catalyzed by one of two condensing enzymes (ELO or KCS) with acyl-CoA (n = 14–30) and malonyl-CoA as substrates.
The structural basis of fatty acid elongation by the ELOVL …
网页2021年6月1日 · Very long chain fatty acids (VLCFAs) are essential building blocks for synthesis of the ceramides and sphingolipids. The first step in the fatty acid elongation cycle is catalysed by the 3-keto acyl-CoA synthases (in mammals, ELOVL elongases).
Mammalian Fatty Acid Elongases - PMC - National Center for ...
网页Fatty acid elongation occurs in three cellular compartments: the cytosol, mitochondria, and endoplasmic reticulum (microsomes). In the cytosol, fatty acid elongation is part of de novo lipogenesis and involves acetyl-CoA carboxylase and fatty acid synthase.
Fatty acid elongases in mammals: their regulation and roles in ...
网页In this review, we will present and discuss the regulation of the mammalian fatty acid elongases and their potential role in lipid metabolism. We will consider both the biochemical functions of the proteins, as well as their role in a more physiological context.
Fatty Acid Synthase: Structure, Function, and Regulation
网页2022年9月24日 · Fatty acid (FA) biosynthesis plays a central role in the metabolism of living cells as building blocks of biological membranes, energy reserves of the cell, and precursors to second messenger molecules.