NOX2 - Wikipedia
网页NADPH oxidase 2 (Nox2), also known as cytochrome b(558) subunit beta or Cytochrome b-245 heavy chain, is a protein that in humans is encoded by the NOX2 gene (also called CYBB gene). [5] The protein is a superoxide generating enzyme which forms reactive oxygen species (ROS).
Structure of human phagocyte NADPH oxidase in the activated state
网页2024年2月14日 · NOX2 is the catalytic subunit and belongs to the NADPH oxidase family, a group of specialized transmembrane redox enzymes that are responsible for reducing molecular oxygen through the...
Structure of the core human NADPH oxidase NOX2
网页2022年10月14日 · NOX2 is the prototypical member of the NADPH oxidase NOX superfamily and produces superoxide (O 2•−), a key reactive oxygen species (ROS) that is essential in innate and adaptive immunity.
NADPH oxidase 2 (NOX2): A key target of oxidative stress …
网页NOX2 is an isoform from NADPH oxidase expressed in platelets and an important regulator of platelet activation-associated thrombosis. The present article aims to highlight the relative contribution of NOX2 as a key target of different platelet …
Structure, Activation, and Regulation of NOX2: At the Crossroad …
网页2023年2月9日 · NOX2 is the catalytic domain that operates the transfer of electrons across the membrane, from NADPH to molecular oxygen. Its domain includes six membrane-spanning helices connected by five loops (designated from A to E from the N-terminal extremity to the C-terminal extremity).
Unlocking the power of NOX2: A comprehensive review on its role …
网页2023年6月22日 · NOX2 (aka phox or gp91 phox, the main subunit of the NOX2 enzymatic complex) was the first identified NOX . NOX2 is mainly expressed in phagocytes (eosinophils, neutrophils, macrophages and dendritic cells (DC)).
NOX2 As a Target for Drug Development: Indications, Possible ...
网页2015年8月8日 · Oxidative stress and NOX enzymes appear to participate in the pathobiology of asthma, but it is not yet clear which isoform is likely to represent the best target for drug development. Blood of asthmatic children showed elevated biomarkers of oxidative stress (203).
p47phox, the phagocyte NADPH oxidase/NOX2 organizer: …
网页2009年4月30日 · This multicomponent enzyme system is composed of two transmembrane proteins (p22phox and gp91phox, also called NOX2, which together form the cytochrome b 558) and four cytosolic proteins...
NADPH Oxidases (NOX): An Overview from Discovery, Molecular …
网页2021年6月1日 · Catalytic subunit of the NADPH phagocyte oxidase complex. NOX2 topology harbors 6 membrane-spanning helices inter-connected by intra and extracellular loops, as well as a cytosolic domain enclosing FAD and NADPH-binding domains. Helices 3 and 5 of NOX2 chelate two b-type heme groups.
NOX2-dependent regulation of inflammation - PubMed
网页2016年4月1日 · The phagocyte NADPH oxidase (NOX2) is critical for antimicrobial host defence. Chronic granulomatous disease (CGD) is an inherited disorder of NOX2 characterized by severe life-threatening bacterial and fungal infections and by excessive inflammation, including Crohn's-like inflammatory bowel disease (IBD).