在新选项卡中打开链接
  1. Nature
    https://www.nature.com/articles/s41419-023-06024-3

    Carcinogenesis promotion in oral squamous cell carcinoma: …

    • Oral squamous cell carcinoma (OSCC) is the most prevalent cancer of the mouth, characterised by rapid progression and poor prognosis. Hence, an urgent need exists for the development of predictive targets f… 展开

    Introduction

    Oral squamous cell carcinoma (OSCC) is the most prevalent head and neck squamous cell … 展开

    Nature
    Results

    Upregulation of LEF1 correlates with OSCC progression
    Although LEF1 overexpression has been reported in OSCC [14], its role in OSCC progression rem… 展开

    Nature
    Discussion

    The transcription factor LEF1 belongs to the T-cell factor (TCF)/LEF family and is known for its role in cancer cell migration, invasion, proliferation, and viability [37, 38]. However, the rol… 展开

    Nature
    Materials and methods

    Cell culture and transfection
    The CAL-27 cells used in this study were obtained from Procell Life Science & Technology Co., Ltd. (Wuhan, China); the SCC-9 cells wer… 展开

    Nature
    Data availability

    The data generated here are available in the article and its supplementary files. The expression profile data analysed here were obtained from The Cancer Genome Atlas (TCGA) Head an… 展开

    Nature
    反馈
    目录
    Introduction
    Results
    Discussion
    Materials and methods
    Data availability
    What does KDM4A do?
     
  1. SAGE Journals
    https://journals.sagepub.com/doi/10.1177/0…

    Astrocyte KDM4A mediates chemokines and drives …

    网页2023年11月26日 · To gain a better understanding of the role of astroglial KDM4A in the pathological process of cerebral ischemia/reperfusion (I/R), we ablated the Kdm4a gene under the promoter of mice GFAP via the …

  2. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S2352304223000272

    The emerging roles of lysine-specific demethylase 4A in cancer ...

  3. GFAP Kdm4a 的研究
    ScienceDirect
    Review article The emerging roles of lysine-specific demethylase 4A in cancer: Implications in tumorigenesis and therapeutic opportunities
    Lysine-specific demethylase 4 A (KDM4A, also named JMJD2A, KIA0677, or JHDM3A) is a demethylase that can remove methyl groups from histones H3K9me2/3, H3K36me2/3, and H1.4K26me2/me3. Accumulating evidence suggests that KDM4A is not only involved in body homeostasis (such as cell proliferation, migra...
    已发布: 2024/03/01
    Cited By: 0
    Keywords: Cancer the…
    ScienceDirect
    Gene-Specific Methylation Control of H3K9 and H3K36 on Neurotrophic BDNF versus Astroglial GFAP Genes by KDM4A/C Regulates Neural Stem Cell Differentiation
    Neural stem cell (NSC) state and fate depend on spatially and temporally synchronized transcriptional and epigenetic regulation of the expression of extrinsic signaling factors and intrinsic cell-specific genes, but the functional roles for chromatin-modifying enzymes in neural differentiation remai...
    已发布: 2014/10/09
    Cited By: 0
    Keywords: NSC neural …
    ResearchGate
    Increase in GFAP-positive astrocytes in histone demethylase GASC1/KDM4C/JMJD2C hypomorphic mutant mice
    GASC1, also known as KDM4C/JMJD2C, is a histone demethylase for histone H3 lysine 9 (H3K9) and H3K36. In this study, we observed an increase of GFAP-positive astrocytes in the brain of Gasc1 hypomorphic mutant mice at 2-3 months of age, but not at postnatal day 14 and day 30 by immunohistochemistry....
    作者: Genki Sudo, Tets…
    已发布: 2016/01/25
    DOI: 10.1111/gtc.12331
    National Center for Biotechnology Information
    Carcinogenesis promotion in oral squamous cell carcinoma: KDM4A complex-mediated gene transcriptional suppression by LEF1
    Oral squamous cell carcinoma (OSCC) is the most prevalent head and neck squamous cell carcinoma (HNSCC), with an annual incidence of approximately 4 per 100,000 [1, 2]. The risk factors of OSCC are complex, and the disease is characterised by a lack of symptoms in the early stage, strong invasivenes...
    作者: Yiming Hou, Wen…
    已发布: 2023/08
    Publication: Cell Deat…
  4. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S0022283614001922

    Gene-Specific Methylation Control of H3K9 and H3K36 on …

  5. Cell Press
    https://www.cell.com/molecular-cell/fulltext…

    Targeting KDM4A epigenetically activates tumor-cell

    网页2021年5月20日 · Zhang et al. show that targeting KDM4A activated tumor-cell-intrinsic immunity by inducing heterochromatin compaction and replication stress. The combination of PD1 blockade and KDM4A …

  6. ResearchGate
    https://www.researchgate.net/figure/KDM4…

    KDM4A and KDM4C knockdown in embryonic NSCs …

    网页In line with our hypothesis, previous research showed that loss of KDM4A/C mediates an increase in glial fibrillary acidic protein (GFAP) expression, which correlates with increased H3K36me3...

  7. 其他用户还问了以下问题
    Does loss of kdm4a/c increase glial fibrillary acidic protein (GFAP) expression?
    In line with our hypothesis, previous research showed that loss of KDM4A/C mediates an increase in glial fibrillary acidic protein (GFAP) expression, which correlates with increased H3K36me3 and RNA polymerase II recruitment in transcribed regions, as well as the promoter, without impacting H3K9me3 in the GFAP promoter .

    Carcinogenesis promotion in oral squamous cell carcinoma ... - Nature

    nature.com
    Does KDM4A loss increase the number of gfp-hp1 puncta?
    KDM4A loss significantly increased the number of GFP-HP1γ puncta (Figure S4 G), consistent with the upregulated puncta of endogenous HP1γ in 4AKO cells. According to the levels of GFP-HP1γ, cells were dichotomous as high- and low-expression groups.

    Targeting KDM4A epigenetically activates tumor-cell ... - Cell Press

    cell.com
    What does KDM4A do?
    As an epigenetic eraser, KDM4A plays pivotal roles in many physiological processes and mediates cell proliferation, differentiation, stemness, and development in a demethylase-dependent or demethylase-independent manner (Table 1).

    The emerging roles of lysine-specific demethylase 4A in cancer

    sciencedirect.com
    Does KDM4A depletion increase cytosolic ssDNA and dsDNA?
    KDM4A depletion increased both cytosolic ssDNA and dsDNA in SCC23 cells (Figure 4 A) and SCC1 cells (Figure 4 B).

    Targeting KDM4A epigenetically activates tumor-cell ... - Cell Press

    cell.com
    Is KDM4A required for satellite cell proliferation and differentiation?
    Fig. 3: KDM4A is required for satellite cell proliferation and differentiation. a Immunofluorescence analysis of Pax7+ satellite cells (white arrows) in control and KDM4A cKO mice (4 months of age). Laminin staining (green) delineates the myofibers. Nuclei are counterstained with DAPI (blue).

    KDM4A regulates myogenesis by demethylating H3K9me3 of myog…

    nature.com
    Does KDM4A demethylase reduce HP1 condensates in 4ako cells?
    The increase in HP1γ condensates in 4AKO cells was significantly reduced by restoring KDM4A, but not demethylase-inactivated KDM4A (Figures 5 E and S4 K), suggesting that KDM4A demethylase activity was required to counteract the formation of HP1γ puncta.

    Targeting KDM4A epigenetically activates tumor-cell ... - Cell Press

    cell.com
    反馈
  8. Wiley Online Library
    https://onlinelibrary.wiley.com/doi/10.1111/ejn.16491

    Spinal nerve transection‐induced upregulation of KDM4A in the …

  9. ResearchGate
    https://www.researchgate.net/publication/291947069...

    Increase in GFAP-positive astrocytes in histone ... - ResearchGate

  10. Nature
    https://www.nature.com/articles/s41419-021-03799-1

    KDM4A regulates myogenesis by demethylating H3K9me3 of …

  11. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/gene/24387

    Gfap glial fibrillary acidic protein [ (Norway rat)]